Aliens Essays (3884 words) - Ufologists, Unidentified Flying Object

Aliens -- Copyright Information -- ? 1999 SIRS Mandarin, Inc. -- SIRS Researcher Spring 1999 Title: Scientists: UFO Reports May Be Worth Evaluating Author: Michelle Levander Source: San Jose Mercury News (San Jose, CA) Publication Date: June 28, 1998 Page Number(s): n.p. --------------------------- SAN JOSE MERCURY NEWS (San Jose, Calif.) June 28, 1998, n.p. (c) 1998, Knight-Ridder Newspapers. Distributed by Knight-Ridder/Tribune Information Services. SCIENTISTS: UFO REPORTS MAY BE WORTH EVALUATING by Michelle Levander Mercury News Staff Writer For more than 50 years, UFO investigators have scoured the skies for signs of alien life--completely snubbed by the scientific community as cranks. But today, in the first independent scientific review of UFO evidence in nearly 30 years, scientists gave a faint nod in their direction by concluding that it might be worthwhile to evaluate UFO reports, marking a major and important shift in the eyes of some UFO investigators. What we need are more scientists looking at this area if we are going to get answers, said Peter Sturrock, the Stanford University physicist who convened the international panel of skeptical scientists. Sturrock assembled the group after being approached by New York philanthropist Laurance S. Rockefeller, the grandson of John D. Rockefeller and someone who reportedly has a longstanding interest in UFOs and psychic phenomena. Sturrock, whose Society for Scientific Exploration promotes the examination of ideas outside the scientific mainstream, hopes the panel's review of UFO reports, to be published today in the alternative Journal of Scientific Exploration, spurs more solid research in the arena. To be sure, after a rare meeting between scientists and UFO investigators, the scientific panel remained skeptical. Nevertheless, they said the scientific community's refusal to even entertain the analysis of such information has been counterproductive. The history of Earth science includes several examples of the final acceptance of phenomena originally dismissed as folk tales, such as meteorites and sprites, the report says. It may therefore be valuable to carefully evaluate UFO reports to extract information about unusual phenomena currently unknown to science. One UFO investigator was pleased with the findings. OPENNESS, EVIDENCE Mark Rodeghier, of the Center for UFO Study in Chicago, interprets the panel's greater openness as an important step to bring the world of science--which demands empirical evidence-- closer to that of UFO observers, some of whom believe they now know what aliens do during human abductions. Taking a break from the national Mutual UFO Network conference, Rodeghier said, It would be extremely important for us to know if aliens are visiting the Earth surreptitiously. I didn't expect in five days that they would change their mind completely. I think it's sufficient that they say the subject deserves study. For its review, the panel examined evidence such as a 1981 photograph of a silvery oval-shaped object set against the blue sky, taken in British Columbia--the photographer swears it was not a trick photo of a frisbee--and a 1965 report by two French submarine crews in Martinique of a large luminous object (that) arrived slowly and silently from the west, flew to the south...and vanished like a rapidly extinguished light bulb. The last time scientists took a serious look at UFOs was in 1968, when Dr. Edward U. Condon, director of the Colorado Project, undertook a two-year study sponsored by the Central Intelligence Agency and the U.S. Air Force. His dismissive conclusion: Nothing has come of the study of UFOs in the past 21 years...and further extensive study of UFOs probably cannot be justified... Already some of this panel's scientists are steeling themselves for ridicule from peers. I haven't gone around and advertised I've done this. I thought I'd wait until our report came out and then let them take their jabs then, said Thomas Holzer, senior scientist at the National Center for Atmospheric Research. Still, he adds, he shares the panel's view that more openness is needed. NATURAL PHENOMENA Some UFO reports, the scientists concluded, could be explained by rare natural events such as sprites, or what appear to be huge sheets of light moving upward from cloud decks caused by electrical activity high above thunderclouds. Unusual radar patterns that UFO investigators interpret as flight patterns of alien craft are likely radar echoes caused by refraction in the atmosphere, said panel member and Stanford professor Von Eshleman, who studies the structure of the atmosphere through experiments on U.S. space missions. And, the scientists said, some in their community may be more

The World Goes Bang Band BOOM essays

The World Goes Bang Band BOOM essays ~recited by Japanese Emperor in 1945 On August 6, 1945 at 8:15am history was made. The first atomic bomb called "Little Boy" was dropped in Hiroshima, Japan. Again on August 9 a second bomb was dropped on Nagasaki, Japan. Hundreds of thousands of people died. With hundreds of thousands more injured. These days of radioactive heat rays of more then 3000 degrees Celsius instantly burning skin, bulldozing houses and even evaporating human existence was not needed to win war over Japan, nor should it have been. Causing a constant flow of deaths either instantaneously, or through untreatable radiation poison, these bombs were not needed. Creating cancer, leukemia, mental retardation, chromosomal "aberrations" and other lingering abnormalities, these bombs were not needed. Over 50 years later still having an operational 170 bed A-bomb hospital filled with continual suffering, these bombs were not needed. There is questions about this incident that have been asked around the globe for centuries, "Should the United States had dropped the Atomic bomb on Japan? Was it really necessary? Did they have to drop two? Did they have proper motives?" And more. A constant phrase comes up in all books, documents, and diaries regarding the decision to drop the A-bomb, that is that their main justification for using this weapon was, "to help save American lives in the Japanese war." However, what the US didn't consider was how the rest of the world including the American people, would accept use of this deathly device and if in fact their motive would actually be justified. Which most facts point to no. ~*~ Japan had officially gone to war shortly after they made their alliance with Germany in June 1941. This action caused the US, England, Netherlands, Philippines, and New Zealand to set an embargo on all goods for Japan leaving them without a drop of oil and other goods. At first this did not have much effect on the Japa...

Fictional hospitality operation -wedding event company- Essay

Fictional hospitality operation -wedding event company- - Essay Example Everything is designed with you, making certain your wedding day is truly individual. Our chefs are talented, unique, flexible and happy to meet the growing and personalized demands of each client. In 5 years, B & G will have a large network of customers in the neighboring regions with high exposure through a number of advertising techniques and through customer referrals. B & G will be a recognised events venue with a large clientele base and more function halls to accommodate for increasing customers. We make full custom packages for any budget - we even offer free wedding advertising through web or through media such as billboards, flyers, television, newspaper ads and radio. Advertising campaigns and websites for B & G have been made to assist the owner in becoming a known and distinguished wedding reception business. We evaluated the strengths, weaknesses, opportunities and threats involved in our wedding planning venture. A SWOT analysis can help establish a current position, and helps analyze reasons for the position of the firm. The prime function of the business is providing great service for own clients. Putting a smile on people’s faces is definitely important to our business, as gaining consumer loyalty and trust is very important, which is exactly outlined in the firm mission statement. These include: improve rostering and scheduling processes of arranging staff; use latest technology to help business perform different functions; finance; improve management accounting and reports for simple decision making; strategic goals; etc. The third objective that B & D wishs to complete relates to the staff members and keeping all employees happy and motivated. To keep all employees motivated, loyal to the firm and to keep working to the best of ones ability our company must provide the staff with monetary and non-monetary benefits. This strategy will work by using these benefits to ensure that the workplace is

Reading Responses of Long Day's Journey Into Night by O'neill, Essay

Reading Responses of Long Day's Journey Into Night by O'neill, Copyright 02 - Essay Example Most prominent in the book is the theme of addiction and drug abuse. The man of the family, James Tyron, is a worried man about his sons and wife. Mary, the wife is nursing morphine addiction as Edmund and Jamie struggle with alcohol addiction. In addition to these struggles, James has financial problems despite being a considerably wealthy man. All his wealth is tied up in assets. These tribulations befalling a man at the same time would make the strongest of men to crumble. Further, Tyron’s family is in chaos with itself. Everyone has problems and no one is willing to take responsibilities for anyone’s muddle. Act II begins as Jamie and Edmund taunt each other over stealing their father’s liquor. The two sons steal their father’s wine and top it up with water so that their father does not realize. Jamie is suspicious over everything. Edmund has an involving task of supervising his mother not to resume abusing morphine despite his addiction. He cares for his mother and is worried about her condition despite himself. Edmund is reluctant to take a test to ascertain his health condition for the fear of traumatizing his mother. He suffers but perseveres it for his mother’s sake. He says: promise not to worry yourself sick and to take care of yourself (ONeill, 23). O’Neill’s work is full of tension. James’s house is full of suspicion. In Act II, Edmund accuses his brother of being suspicious over everything. The characters in the play contribute to the dissonance. Jamie’s suspicion causes tension in the house. He complains that he had been put in the dark for 10 years about his mother’s addiction. He, therefore, trusts no one in the family. To him, everything that goes on is akin to a scheme. Moreover, the two sons are not sure of their mother’s morphine addiction state. When Mary left the main bedroom to go sleep in a spare bedroom due to her husband’s snore, Edmund suspected she was up

EDU 636 DB 5 Research Paper Example | Topics and Well Written Essays - 500 words

EDU 636 DB 5 - Research Paper Example Gagne’s Events of Instruction and Technology The learning environment has undergone massive changes with the integration of technology in the classroom over the past few decades. Schools have gone from mostly pencil and paper based learning to many students having their own laptops in the classroom. This shift has created a need for teachers to understand how to keep their students interested and engaged in the classroom, by presenting information in the most meaningful way. The basic structure for learning events as Gagne presented in his book, The Conditions of Learning, published in 1965, however, have not changed. So it is imperative to make the connection between the learning and teaching tools now available and how best to integrate them into Gagne’s nine events of instruction. To demonstrate this, an in-depth look into the difference between the following will be investigated in accordance with how they tie into Gange’s events of instruction: an instructio nal presentation and an instructional learning module, and an instructional authoring tool and a conventional presentation tool.

Hillary Clinton Email Scandal

Hillary Clinton Email Scandal Hillary Clinton has been a topic of discussion for a while with the entire email scandal. Rumor has it she has been using a private email and has given out classified information on said email. The basis of the whole scandal lies on the question; should Hillary be searched and prosecuted for the emails? Hillary has been using a private email server for over 3 years without question. But suddenly with the election here she has begun to be questioned and has also been searched as shown by Patrick Howley The FBI has a search warrant for Clinton aide Huma Abedins laptop, obtained Sunday night after new emails surfaced in the law enforcement investigation of Abedins husband Anthony Weiner for allegedly sexting with a minor. so the FBI not only searched Hillarys laptop but also Abedins laptop. The FBI has found about five emails on Hillarys server that show classified information such as the location or travel plans for Libyan ambassador Chris Stevens who was killed in 2012. This is very suspicious because his killer knew exactly where he would be and the locations happen to be where he was going when he died. That sounds a bit suspect; why would she know the location of where he would eventually die? Clintons private email allowed her to communicate with many world leaders and to swap em ails with the Clinton foundation. Clintons partner, Huma Abedin, was nervous because in fact she was the one who came up with the idea of creating the private email server. This makes her a suspect if the investigation was ever brought into trial, who has to say that Hillary wont throw Abedin under the bus to save herself from prosecution? Even though Abedin was the one who came up with the idea she said she didnt know about it Huma Abedin later told the FBI that she didnt even know about Clintons private server when she was at the State Department, and Bryan Pagliano pleaded the Fifth(Patrick Howley). Clinton tried to cover up her story saying that her server was kept in the basement of her Chappaqua, New York home. But really, the server was stored at a Clinton-owned office in Midtown Manhattan, where it shared physical space with the Clinton Foundations server. Hillarys homebrew server was operating on the same email network as the Foundations server and the server for Chelsea Cl intons office. (Patrick Howley). It makes Hillary look bad because shes lying about her emails and where they were sent from. Its still unclear if she can be prosecuted but if she ever is they can use that against her, not helping her case. Hillary might be able to get charged with perjury and obstruction of justice for lying and making false statements to the government. This is why shes not fit to be president despite what all the supporters say. Hillary exposed confidential information, Hillary Clinton posted and shared the names of CIA-protected intelligence sources on her private email server, including a defense attachà © and other covert U.S. agents working on matters including Iran and the Taliban and Pakistan (Patrick Howley). This can very well secure the prosecution of Clinton, but why Clinton has not been prosecuted is puzzling. Her server contained five emails with exact locations of travel plans of Chris Stevens and the location of his murder by a 2012 Benghazi attack . Who knows if she was a part of the attack, but it is scary to think that is a possibility. In July, an FBI investigation concluded no reasonable prosecutor would bring a criminal case against Mrs. Clinton, but that she and her aides were extremely careless in their handling of classified information. (Anthony Zurcher). Clinton carelessness should make it possible for a prosecution because there is evidence that could be incriminating to her. The FBI surprised everyone, 11 days before the election, by announcing it was examining newly discovered emails sent or received by Hillary Clinton (Anthony Zurcher). These new emails may contain incriminating items but it is unknown because the government hasnt released any info about the emails. Although with incriminating statements by Clinton, the FBI director James Conrey stood by the statement saying that Clinton should not be prosecuted. Shortly before she was sworn in as secretary of state in 2009, Hillary Clinton set up an email server at her home in Chappaqua, New York. She then relied on this server, home to the email addres s [emailprotected], for all her electronic correspondence both work-related and personal during her four years in office (Anthony Zurcher). While Hillary was secretary of state, she sent or received 62,320 emails. 30490 of those are official but the other ones are not, what does this say about the other ones? Maybe the other emails have illegal information or are sent over her private email. Many of her private emails released to the public had information about the 2012 attack on the US consulate in Benghazi. Hillary has claimed that she had to use her private email for business related things although she never stated why. George W. Bush stated in Clintons defense that he as well used private emails while he was in office. The State Department inspector general report found that many of Mrs. Clintons predecessors including Mr. Powell were also not in compliance with federal recordkeeping requirements, although the rules governing their actions were less detailed when they were in office (Anthony Zurcher). Mr. Powell told Hillary to use private emails but stated that she should not use that email for private information or classified information. Hillary Clintons email controversy is older than her 2016 presidential campaign and its been forced into the headlines again Thursday and Friday when two top aides testify behind closed doors for a House committee(Eric Bradner). Even though the private email scandal is risky for her legally and it can affect her respect level, she said she used it for sole convenience purposes. The FBI believe that she didnt use them for convenience purposes but to have more control over the emails because the government emails that she was supposed to use were monitored. Clinton believes that it is just easier to use the private emails despite the consequences. Clinton got out of trouble because the FBI released information about Hillary knowing that she willingly sent emails that shared classified information. That was supposed to be kept classified but was not. But the Justice Departments investigation, the State Departments processing and release of her emails, a House panels separate investigat ion and dozens of impending lawsuits are weighing on the 2016 Democratic presidential front-runners campaign(Eric Bradner). Hillarys lawyers turned over about 55000 pages of emails found on her private email server to the State Department. Some of the emails were released under judges order. Even though her emails contained classified information, the government still has to deem them classified. But Clintons emails are being reviewed by a team of about 12 interagency officials, who are making recommendations on what should and shouldnt be classified(Eric Bradner).   Clinton has been called into a closed-door deposition by Trey Gowdy. Trey is a part of the house of Benghazi committee. This could be bad considering some of her emails had the travel plans and location of someones death in Benghazi. We do not know what happened in that deposition but it could not have gone badly because Hillary is still free. Clintons email server was run under Eric Hoteham which was a misspelled version of one of her former aids named Eric Hothem. Hillary used google as a backup server, which was traced by the government. The government found out about the emails through a Romanian hacker named Guccifer. President Barak Obama further signed an update to federal records stating that private emails are legal and can be used. Although he stated that they government further made it illegal to use private emails unless they forward or copy the emails to their government emails within twenty days of sending the emails. March 3, 2015 State Department spokeswoman Maria Harf says: [Theres] no indication that Secretary Clinton used her personal email account for anything but unclassified purposes While Secretary Clinton did not have a classified email system, she did have multiple other ways of communicating in a classified manner, including assistants printing documents for her, secure phone calls and secure vi deo conferences(Eric Bradner). This could very well further the investigation because they state that she used other forms of communication to spread classified information. So the FBI could look into her phone records and other forms of communication to potentially find incriminating information. Essentially, this scandal effects all of us because with the presidential election happening she could have become our president and with her on the verge of prosecution why would anyone want that type of person to be a leader of a country. Hillary has   not been publicly registered as the domain owner of the of the email server making her less responsible for her actions as said in the CNN news report. The FBI has stated that have been watching the scandal without involvement for awhile just waiting for Hillary to slip up, which she did to go investigate but when the investigation happened she was deemed being lawful and not breaking any rules so the prosecution is in a standstill waiting for something unlawful to air so that Clinton can be brought up on charges. The fact of the matter is CLinton did something suspicious and illegal and just because the president decided to change a rule last minute to save Hillary shouldnt be counted because before that rule change Clinton could have been prosecuted and brought into court but wasnt. Clinton is very lucky for Obama helping her and should count her blessings for the simple fact that she should be in brought into justice, this may be opinionated but maybe she wasnt prosecuted because she has connections in government and she is a part of a serious position that shes done so well. The government doesnt want to see her go because theyd have to find someone who might not be able to do it as well as her. The email scandal is a serious debate and should be looked into by the FBI. Due to the evidence I believe that Clinton should be prosecuted for her actions of sending classified information. All in all the case has been opened and hopefully will be closed soon with Clinton getting what she deserves. Works Cited Hillary Clinton Email Scandal Explained. Hillary Clinton Email Scandal Explained, Breitbart, 2017, www.breitbart.com/2016-presidential-race/2016/10/31/hillary-clinton-email-scandal-explained/. Accessed 3 Mar. 2017. Hillary Clinton Email Scandal Explained. Hillary Clinton Email Scandal Explained, Investors Business Daily, Inc, 20 Jan. 2017, www.investors.com/politics/editorials/hillary-clinton-email-scandal/. Accessed 3 Mar. 2017. Hillary Clinton emails whats it all about? Hillary Clinton emails whats it all about?, BBC News Services, 6 Nov. 2016, www.bbc.com/news/world-us-canada-31806907. Accessed 3 march 2017. Hillary Clintons email controversy, explained. Hillary Clintons email controversy, explained, http://www.cnn.com/profiles/eric-bradner, 28 Oct. 2016, www.cnn.com/2015/09/03/politics/hillary-clinton-email-controversy-explained-2016/. Accessed 3 Mar. 2017.

Wordsworths Ode: Intimations of Immortality :: Wordsworth Ode immortality intimations Essays

Wordsworth's Ode: Intimations of Immortality The fifth stanza of Wordsworth’s â€Å"Ode: Intimations of Immortality† is especially interesting to me because of the images it presents. It is at this point in the poem that Wordsworth resumes his writing after a two-year hiatus. In the fourth stanza, he poses the question, â€Å"Whither is fled the visionary gleam?† Stanza five is the beginning of his own answers to that question. Contrary to popular enlightenment ideas, Wordsworth suggests that rather than become more knowledgeable with age, man if fact is born with â€Å"vision splendid† and as he ages, that vision â€Å"dies away† and he left empty. This stanza is dominated by the Christian ideas of being made in God’s image. However, man does not remain in that image. His â€Å"birth is but a sleep and a forgetting,† and as his life progresses he moves farther and farther from the glorious ideal he had in childhood. Throughout much of his poetry, Wordsworth asserts that in childhood, one can â€Å"see† but is unaware of that ability, whereas in adulthood, one cannot see and is painfully aware of his situation. It is only through conscious thought and reflection that man can begin to find a state similar to his original one. The question, then, is why children, who take nature for granted, are given the opportunity to connect so closely with it. It would appear that the fact that children do not realize what they have is the very reason for their having it. Thus, the losing of that knowledge with age allows man to feel the loss, and forces him to find a solution, just as Wordsworth has done. In stanz a ten, he tells the reader that the true essence of humanity is the ability to feel pain and have memories of better times. Through these painful or happy memories, man is able achieve the philosophical state of mind, and in the end to love nature â€Å"even more† than he did in youth.

Haemoglobinopathy

Review Article Indian J Med Res 134, October 2011, pp 552-560 Invasive & non-invasive approaches for prenatal diagnosis of haemoglobinopathies: Experiences from India R. B. Colah, A. C. Gorakshakar & A. H. Nadkarni National Institute of Immunohaematology (ICMR), Mumbai, India Received October 29, 2010 The thalassaemias and sickle cell disease are the commonest monogenic disorders in India. There are an estimated 7500 – 12,000 babies with ? -thalassaemia major born every year in the country. While the overall prevalence of carriers in different States varies from 1. to 4 per cent, recent work has shown considerable variations in frequencies even within States. Thus, micromapping would help to determine the true burden of the disease. Although screening in antenatal clinics is being done at many centres, only 15-20 per cent of pregnant women register in antenatal clinics in public hospitals in the first trimester of pregnancy. There are only a handful of centres in major cities in this vast country where prenatal diagnosis is done. There is considerable molecular heterogeneity with 64 mutations identified, of which 6 to 7 common mutations account for 80-90 per cent of mutant alleles. First trimester foetal diagnosis is done by chorionic villus sampling (CVS) and DNA analysis using reverse dot blot hybridization, amplification refractory mutation system (ARMS) and DNA sequencing. Second trimester diagnosis is done by cordocentesis and foetal blood analysis on HPLC at a few centres. Our experience on prenatal diagnosis of haemoglobinopathies in 2221 pregnancies has shown that >90 per cent of couples were referred for prenatal diagnosis of ? -thalassaemia after having one or more affected children while about 35 per cent of couples were referred for prenatal diagnosis of sickle cell disorders prospectively. There is a clear need for more data from India on non-invasive approaches for prenatal diagnosis. Key words Haemoglobinopathies – India – invasive and non-invasive approaches – prenatal diagnosis Introduction The inherited disorders of haemoglobin are the most common monogenic disorders globally. Around 7 per cent of the population worldwide are carriers with more than 3,00,000 severely affected babies born every year1. Prenatal diagnosis is an integral component of a community control programme for haemoglobinopathies. Estimating the disease burden, generating awareness in the population, screening 552 o identify carriers and couples at – risk and genetic counselling are prerequisites for a successful prevention programme. The remarkable success of such programmes in the 1970s in Cyprus, Italy, Greece and the UK led to the development of control programmes in many other countries2-6. The extent of the problem in India ? -thalassaemia has been reported in most of the communities that have been screened so far in India. While the overall prevalence varies from 1. 5 to 4 per COLAH et al: PRENATAL DIAGNOSIS OF HAEMOGLOBINOPATHIES IN INDIA 553 ent in different States, communities like Sindhis, Punjabis, Lohanas, Kutchi Bhanushalis, Jains and Bohris have a higher prevalence (4-17%)7-12. Different reportshaveestimatedthat7500-12,000? -thalassaemia major babies would be born in India each year12 -14. It has also been shown recently by micromapping at the district level in two States, Maharashtra and Gujarat in westernIndiathattheprevalenceof? -thalassaemiatrait in different districts within these States is variable (0 9. 5%). Based on these estimates there would be around 1000birthsof? thalassaemiamajorbabieseachyear in these two States alone15. Thus, such data should be obtained from different States to know the true burden of the disease and for planning and executing control programmes. Haemoglobin S (Hb S) is prevalent in central India and among the tribal belts in western, eastern and southern India, the carrier rates varying from 1-40 per cent16-18. It has been estimated that over 5000 babies with sickle cell disease would be born each year19. Haemoglobin E is widespread in the north eastern States in Assam, Mizoram, Manipur, Arunachal Pradesh and Tripura, the prevalence of Hb E trait being highest (64%) among the Bodo-Kacharis in Assam and going up to 30-40 per cent in some other populations in this region20-22. In eastern India the prevalence of Hb E trait varies from 3-10 per cent in West Bengal8,23. Both Hb E andHbSwhenco-inheritedwith? -thalassaemiaresult in a disorder of variable clinical severity24-26. These inherited haemoglobin disorders cause considerable pain and suffering to the patients and their families and are a major drain on health resources in the country. The need for accurate identification of carries and couples at risk Classical ? thalassaemia carriers have typically reduced red cell indices [mean corpuscular volume (MCV)T) ? + 3. -87 (C>T) ? + 4. -80 (C>T) ? + 5. -29 (A>G) ? + 6. -28 (A>G) ? + 7. -25 (A>G) ? + B. Cap site 1. +1 (A>C) ? + C. Initiation codon 1. ATG > ACG ? 0 D. RNA processing mutations i) Splice junction site 1. Codon 30 (G>C) ? 0 2. Codon 30 (G>A) ? 0 3. IVS 1-1 (G>T) ? 0 4. IVS 1-1 (G>A) ? 0 5. IVS 1-129 (A>C) ? 0 6. IVS 1-130 (G>C) ? 0 7. IVS 1-130 (G>A) ? 0 8. IVS II-1 (G>A) ? 0 (ii) Consensus site 1. IVS 1-5 (G>C) ? + 2. IVS 1-128 (TAG > GAG) ? + 3. IVS II-837 (T>G) ? (iii) IVS changes 1. IVS I-110 (G>A) ? + 2. IVS II-591 (T>C) ? + 3. IVS II-613 (C>T) ? + 4. IVS II-654 (C>T) ? + 5. IVS II-745 (C>G) ? + iv) Coding region changes 1. Codon 26 (G>A) Hb E ? + E. RNA translational mutations i) Nonsense 1. Codons 4,5,6 (ACT CCT GAG> ACA TCT ? 0 TAG) 2. Codon 5 (-CT), Codon 13 (C>T), Codon 26 ? (G>C), Codons 27/28 (+C) in cis 3. Codon 6 (GAG > TAG) and on the same ? 0 chromosome Codon 4 (ACT> ACA) , Codon 5 (CCT>TCT) 4. Codon 8 (A>G) ? 5. Codon 13 (C>T), Codon 26 (G>A), Codons ? 27/28 (-C) in cis 6. Codon 15 (TGG > TAG) ? 0 7. Codons 62-64 (7 bp del) ? 0 8. Codons 81-87 (22 bp del) ? 9. Codon 121 (G>T) ? 0 Contd†¦. themselves, today their relatives and extended families are coming forward to get screened38. There is only one centre in Lucknow in north India which offers a formal course for genetic counsellors and there is a need for more such courses throughout the country. Counsellors should be aware that couples at risk of havingachildwith? -thalassaemiamajor,sicklecel l disease, Hb S ? -thalassaemia, Hb E ? -thalassaemia, – ? -thalassaemia, Hb Lepore ? -thalassaemia and Hb SD disease should be given the option of prenatal diagnosis to avoid the birth of a child with a severe disorder. However, couples at risk of having a child with Hb D disease, Hb D ? -thalassaemia and Hb E disease do not require prenatal diagnosis as these disorders are mild. InSardinia,identificationofthemaximumnumber of carriers followed by effective genetic counselling helpedtoreducethebirthrateof? -thalassaemiamajor babies from 1:250 to 1:400039. Prenatal diagnosis The first initiatives in India Facilities for prenatal diagnosis became available in India in the mid 1980s40. Until then, although prenatal diagnosis was offered by a few centres, foetal samples were sent to the UK and other countries for analysis. Foetal blood sampling by foetoscopy done between 18 and 22 wk gestation and diagnosis by globin chain synthesis were done for the next 4 to 5 years at 2 centres in Mumbai40,41. Chorionic villus sampling and DNA analysis in the first trimester In the 1990s first trimester foetal diagnosis by chorionic villus sampling (CVS) and DNA analysis was established at 4-5 centres in the north in Delhi42, in the west in Mumbai41,43,44 and in the south in Vellore45. These services then expanded to other cities like Lucknow and Chandigarh in the north46,47, and Kolkata in the east48. However, these services are still limited to major cities where couples are referred to or CVS samples are sent from surrounding areas. Molecular analysis ? -thalassaemia is extremely heterogeneous with more than 200 mutations described worldwide49. In India, about 64 mutations have been characterized by studies done at different centres30,31,49-51 (Table I). Six to seven mutations [IVS 1-5 (G? C), 619 bp deletion, IVS 1-1 (G? T), Codon 8/9 (+G), Codons 41/42 (-CTTT), COLAH et al: PRENATAL DIAGNOSIS OF HAEMOGLOBINOPATHIES IN INDIA (ii) Frameshift 1. Codon 5 (-CT) 2. Codons 7/8 (+G) 3. Codon 8 (-AA) 4. Codons 8/9(+G) 5. Codon 13 (C>T) 6. Codon 15 (-T) 7. Codon 16 (-C) 8. Codon 16 (C>T) 9. Codon 17 (A>T) 10. Codons 22-24 (7 bp del) 11. Codon 26 (G>T) 12. Codon 35 (A>G) 13. Codons 36/37 (-T) 14. Codons 36-39 (8 bp del) 15. Codon 39 (C>T) 16. Codon 44 (-C) 17. Codons 47/48 (+ATCT) 18. Codon 55 (+A) 19. Codon 55 (-A) 20. Codons 57/58 (+A) 21. Codon 88 (+T) 22. Codons 106/107 (+G) 23. Codon 110 (T>C) 24. Codon 111 (-G) 25. Codon 135 (C>T) F. RNA cleavage and polyadenylation mutation 1. AATAAA>AACAAA G. Deletional mutations 1. 619 bp deletion; 3’end 2. 10. 3 kb deletion 3. Codons 126-131 (17 bp deletion) Source: Refs 30, 31, 49-51 55 ?0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? + ? 0 ? + ? 0 ? 0 ? 0 Fig. 1. Regionaldistributionof? -thalassaemiamutationinIndia. molecular techniques like covalent reverse dot blot hybridization (CRDB), amplification refractory mutation system (ARMS), denaturing gradient gel electrophoresis (DGGE), and DNA sequencing43,44 ,52. Foetal blood analysis in the second trimester Most of the prenatal diagnosis programmes in the Mediterranean countries started with second trimester foetal blood analysis but they were able to switch over tofirsttrimesterdiagnosisinashortspan5,39. In India, second trimester diagnosis is still done as manycouplesatriskareidentifiedlateduringpregnancy. Foetal blood sampling is done by cordocentesis at 18 to20wkgestationandafterconfirmingthatthereisno maternal contamination in the foetal sample by foetal cell staining using the Kleihauer-Betke method, it is analysed by HPLC on the Variant Hemoglobin Testing System (Bio Rad Laboratories, Hercules, USA). The HbA levels in foetuses affected with ? -thalassaemia major have ranged from 0 to 0. 5 per cent and these were distinguishable from heterozygous babies where the Hb A levels were >1. per cent in different studies. However, there was some overlap in Hb A levels between heterozygotes and normals53-55. Sickle cell disease and Hb E thalassaemia have also been diagnosed in this way. On the other hand, experience in Thailand showed that while ? 0 thalassaemia homozygotes and HbE-? 0 thalassaemia compound heterozygotes could be diagnosed by HPLC analysis of foetal blood, ? ++ thalassae mia homozygotes may be misdiagnosed as heterozygotes56. Amniotic fluid cells have not been used extensively in India for prenatal diagnosis of haemoglobinopathies. Codon 15 (G? A), Codon 30 (G? C)] are common accounting for 85-95 per cent of mutant alleles. However, regional differences in their frequencies have been noted30,31,50,51 (Fig. 1). The prevalence of IVS 1 -5 (G? C), the most common mutation in India varies from 15-88 per cent in different States. Codon 15 (G? A) is the second most frequent mutation in Maharashtra and Karnataka and Codon 5 (-CT) is the third most common mutation in Gujarat. The -88 (C? T) and the Cap site +1 (A? C) mutations are more common in the northern region30,31,50. The 619 bp deletion is the most common mutation among the immigrant population from Pakistan. This knowledge on the distribution of mutations in different regions and in people of different ethnic backgrounds has facilitated prenatal diagnosis using 556 INDIAN J MED RES, OCTOBER 2011 Experience at National Institute Immunohaematology (NIIH), Mumbai of Bothfirstandsecondtrimesterprenataldiagnosis for the ? -thalassaemias and sickle cell disorders are done at National Institute of Immunohaematology, Mumbai, and over the last 25 years 2,221 pregnancies at risk have been investigated (Table II). While majority of the couples were at risk of having children with ? thalassaemia major, a significant number of couples at risk of having children with sickle cell disorders have been referred for prenatal diagnosis in the last 4 to 5 years. Our experience in western India has shown that there are still very few couples (G; or codon 35 ? (A? G) at alpha -beta chain interfaces. Ann Hematol 2009; 88 : 1269-71. 52. Old JM, Varawalla NY, Weatherall DJ. The rapid detection and prenatal diagno sis of ? -thalassemia in theAsian Indian and Cyproit populations in the UK. Lancet 1990; 336 : 834-7. 53. Rao VB, Natrajan PG, Lulla CP, Bandodkar SB. Rapid midtrimester prenatal iagnosis of beta-thalassaemia and other haemoglobinopathies using a non- radioactive anion exchange HPLC technique – an Indian experience. Prenat Diagn 1997; 17 : 725-31. 54. Wadia MR, Phanasgaokar SP, Nadkarni AH, Surve RR, Gorakshakar AC, Colah RB, et al. Usefulness of automated chromatography for rapid fetal blood analysis for second trimester prenatal diagnosis of beta-thalassemia. Prenat Diagn 2002; 22 : 153-7. 559 55. Rao S, Saxena R, Deka D, Kabra M. Use of HbA estimation by CE-HPLC for prenatal diagnosis of beta-thalassemia; experience from a tertiary care centre in north India: a brief report. Hematology 2009; 14 : 122-4. 56. Winichagoon P, Sriphanich R, Sae-Mgo WB, Chowthaworm J, Tantisirin P, Kanokpongsakdi S, et al. Application of automated HPLC in prenatal diagnosis of thalassemia. Lab Hematol 2002; 8 : 29-35. 57. Holzgreve W. Will ultrasound screening and ultrasound guided procedures be replaced by non-invasive techniques for the diagnosis of fetal chromosome anomalies? Ultrasound Obstet Gynecol 1997; 9 : 217-9. 58. Steele CD, Wapner RJ, Smith JB, Haynes MK, Jackson LG. Prenatal diagnosis using fetal cells isolated from maternal peripheral blood. Clin. Obstet Gynecol 1996; 39 : 801-13. 59. Mesker WE, Ouwerkerk-vn Velzen MC, Oosterwijk JC, Bernini LF, Golbus MS, Kanhai HH, et al. Two colour immunocytochemical staining of gamma and epsilon type hemoglobin in fetal red cells. Prenat Diagn 1998; 18 : 1131-7. 60. Takabayashi H, Kuwabara S, Ukita T, Ikawa K, Yamafuji K, Igarashi T. Development of non-invasive fetal DNA diagnosis from maternal blood. Prenat Diagn 1995; 15 : 74-7. 61. Cheung MC, Goldberg JD, Kan YW. Prenatal diagnosis of sickle cell anemia and thalassemia by analysis of fetal cells in maternal blood. Nat Genet 1996; 14 : 264-8. 62. Di Naro E, Ghezzi F, Vitucci A, Tannoia N, Campanale D, D’ Addario V, et al. Prenataldiagnosisof? -thalassemiausing fetal erythroblasts enriched from maternal blood by a novel gradient. Mol Hum Reprod 2000; 6 : 571-4. 63. Kolialexi A, Vrettou C, Traeger-Synodinos J, Burgemeister R, Papantoniou N, Kanavakis E, et al. Non invasive prenatal diagnosisof? -thalassemiausingindividualfetalerythroblasts isolated from maternal blood after enrichment. Prenat Diagn 2007; 27 : 1228-32. 64. D’Souza E, Sawant PM, Nadkarni AH, Gorakshakar A, Mohanty D, Ghosh K, et al. Evaluation of the use of monoclonal antibodies and nested PCR for non-invasive prenatal diagnosis of hemoglobinopathies in India. Am J Clin Pathol 2008; 130 : 202-9. 65. Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, et al. Presence of fetal DNA in maternal plasma and serum. Lancet 1997; 350 : 485-7. 66. Lo YM, Tein MS, Lau TK, Haines CJ, Leung TN, Poon PM, et al. Quantitaive analysis of fetal DNA in maternal plasma and serum: implications for non invasive prenatal diagnosis. Am J Hum Genet 1998; 62 : 768-75. 67. Lun FMF, Chiu RWK, Allen Chan KC, Lau TK, Leung TY, Dennis Lo YM. Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma. Clin Chem 2008; 54 : 1664-72. 68. Li Y, Zimmermann B, Rusterholz C, Kang A, Holzgrave W, Hahn S. Size separation of circulating DNA in maternal plasma permits ready detection of fetal DNA polymorphisms. Clin Chem 2004; 50 : 1002-11. 69. Chiu RW, Lau TK, Leung TK, Chow KC, Chui DH, Lo YM. Prenatal exclusion of beta thalassemia major by examination of maternal plasma. Lancet 2002; 360 : 998-1000. 560 INDIAN J MED RES, OCTOBER 2011 beta thalassemia point mutation by MALDI – TOF mass spectrometry. Fetal Diagn Ther 2009; 25 : 246-9. Papasavva T, Kalikas I, Kyrri A, Kleanthous M. Arrayed primer extension for the noninvasive prenatal diagnosis of beta thalassemia based on detection of single nucleotide polymorphism. Ann N Y Acad Sci USA 2008; 1137 : 302-8. Li Y, Di Naro E, Vitucci A, Zimmermann B, Holzgreve W, Hahn S. Detection of paternally inherited fetal point mutations for beta thalassemia using size fractionated cell free DNA in maternal plasma. J Am Med Assoc 2005; 293 : 843-9. Chan K, Yam I, Leung KY, Tang M, Chan TK, Chan V. Detection of paternal alleles in maternal plasma for noninvasive prenatal diagnosis in beta thalassemia: a feasibility study in southern China. Eur J Obstet Gynecol Repord Biol 2010; 150 : 28-33. Lo YMD. Non invasive prenatal diagnosis in 2020. Prenat Diagn 2010; 30 : 702-3. 70. Papasavva T, Kalakoutis G, Kalikas I, Neokli E, Papacharalambous S, Kyrri A, et al. Non-invasive prenatal diagnostic assay for the detection of beta thalassemia. Ann NY Acad Sci USA 2006; 1075 : 148-53. 71. Tungwiwat W, Fucharoen G, Fucharoen S, Ratanasiri T, Sanchaisuriya K, Sae- Ung N. Application of maternal plasma DNA analysis for noninvasive prenatal diagnosis of Hb E beta thalassemia. Transl Res 2007; 150 : 319-25. 72. Lazaros L, Hatzi E, Bouba I, Makrydimas G, Dalkalitsis N, Stefos T, et al. Noninvasivefirsttrimesterdetectionofpaternal beta globin gene mutations and polymorphisms as predictors of thalassemia risk at chorionic villus sampling. Eur J Obstet Gynecol Repord Biol 2008; 140 : 17-20. 73. Li Y, Di Naro E, Vitucci A, Grill S, Ahong XY, Holzgreve W, et al. Size fractionation of cell free DNA in maternal plasma improves the detection of a paternally inherited 74. 75. 76. 77. Reprint requests: Dr Roshan Colah, Scientist F, National Institute of Immunohaematology (ICMR), 13th Floor, NMS Bldg, KEM Hospital Campus, Parel, Mumbai 400 012, India e-mail: [email  protected] com

New York by Gas-Light Essays

New York by Gas-Light Essays New York by Gas-Light Essay New York by Gas-Light Essay New York by Gas-Light and Awful Disclosures can be called a number of things, but â€Å"earnest reform tracts† is probably something that should be excluded from the list. New York by Gas-Light has one critical redeeming value: George Foster had a magnificent subject that had largely been unexploited by other journalists in his day: New York City.   New York had grown at an breakneck pace, becoming in just a few decades the first true American metropolis.   At the same time, Americans’ appetite to know about this strange, somewhat sordid place had also grown, and Foster was entirely willing to satisfy the public’s desire to know.   Reading through his fifteen sketches, one finds descriptions intended to arouse and perhaps to shock his readers, but there is no serious call to clean up the vice of the city. Consider a few examples: female prostitution is invariably the result of man’s individual villainy in seducing and betraying the pure being who trusts her destiny to his keeping – or of the monstrous crime of society which dooms its daughters to degradation, want and misery from which no virtuous effort of theirs can ever rescue them.   Let society heed this one simply truth, and apply a thorough and efficient remedy, by furnishing the means of comfortable and happy existence to women who would be virtuous and exclude from its presence all men who are guilty of seduction or libertinism, or who have trifled with the sacred affection of woman, in any form.   The nine-tenths of all crime and suffering will be at once abolished from the face of the earth.   But this is something to be prayed fro rather than hoped for. Indeed, given the prominence that Foster attained through his writing, one wonders how fervently he prayed that these conditions end.   Describing â€Å"Five Points,† he waxes eloquent: This is indeed a sad sight, an awful sight a sight to make the blood slowly congeal and the heart to grow fearful and cease its beatings.   Here, whence these streets diverge in dark and endless paths, whose steps take hold on hell here is the very type and physical semblance, in fact, of hell itself. Foster gives no suggestion that he want to remedy the vices he found in such places as Five Points.   Given the success that he enjoyed with New York by Gas-Light, it seems unlikely he did. New York by Gas-Light is not entirely accurate.   Foster took a number of journalistic liberties in his writing, but it can still be classified as non-fiction.   That cannot be said of Awful Disclosures, which was a calculated fraud.   Maria Monk was never a nun and was never in the Hotel Dieu Nunnery.   Monk had suffered a brain injury as a child, and she apparently could not differentiate between reality and elaborate fictions.   She collaborated with several vehemently anti-Catholic Protestant ministers, to produce a book that described the nunnery in Montreal as an elaborate prison in which nuns were held as slaves for priests. While there is the absence of explicit details about sex acts that might be expected for a piece of this period, there are many details of sadistic punishments meted out against nuns for the slightest resistance.   Infanticide is described in some detail, this being the supposed means of disposing of any accidental children born of the liaisons of the lascivious priests with their sexual servitors. (Monk, 99-101, 128)   Bondage and gagging are described as punishments. (Monk, 105-06, 114-15)   In a remarkably cold scene, she describes the murder of a nun and the dumping of her body into a lime pit. (Monk, 59-65) While Foster wrote New York by Gas-Light as a profit-making venture, the purpose for creating the elaborate hoax of Awful Disclosures is more devious.   The book was created as an attack on Catholicism.   In the 1830s, nativist Protestants felt themselves threatened by Catholicism.   To counter this, and following the literary success of Six Months in a Convent in 1832, Maria Monk’s backers created their pseudo-pornographic account of life in a Montreal nunnery.   The book has since been exposed as completely fictional.   An investigator who was enter the Hotel Dieu Nunnery reported that Maria Monk’s description of the arrangement of the rooms (Monk, 35-40) was hopelessly inaccurate. (Schultz, xv-xix)   As inquiries continued, it was discovered that Maria Monk had never been a nun, had apparently been confined for a considerable time to an asylum, and was a common prostitute rather than the victim of priestly sexual abuse.   Nevertheless, Awful Disclosures remained a remarkable bestseller for many years. (Schultz, xviii-xix)

Extreme Roles essays

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Internship Essay Example | Topics and Well Written Essays - 750 words

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Short Question Answer Essay Example | Topics and Well Written Essays - 1250 words

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